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Furthermore, the lists of approved medical uses for Halobol today have been further reduced, leaving only the treatment of male androgen deficiency and female breast cancer treatment. The issue with Halo is that of its high degree of hepatotoxicity, and through this, its high potential for altering cholesterol profiles negatively. It is for these reasons that physicians and medical professionals have elected to avoid the use of Halobol for any treatment except for that of male androgen deficiency. Even Halobol’s use for andropause or hypogonadism has become limited in the face of simple TRT (Testosterone Replacement Therapy), whereby simple Testosterone administration is not liver toxic in comparison to Halobol. Halobol today still remains available on the prescription market in the United States, still sold by the original manufacturer (Upjohn), but now under the new company name Pharmacia and only in very small and very limited quantities. As previously touched upon, Halobol is a Testosterone derivative whereby it has undergone several modifications. Halo possesses an added methyl group on the 17thcarbon (known as carbon 17-alpha). It is also halogenated at carbon 9-alpha. Halogenation refers to the reaction of an organic compound (in this case, Testosterone) with a halogen, usually resulting in said halogen becoming bound to the compound. A halogen refers to a specific category of 5 related elements on the periodic table (Fluorine, Chlorine, Bromine, Iodine, and Astatine). In Halobol’s case, this is essentially Testosterone that has been halogenated with Fluorine (as a fluoro group) whereby the Fluorine atom has been bound to carbon 9-alpha. The final modification that Halobol possesses is its addition of a hydroxyl group (an oxygen atom bound to a hydrogen atom) at carbon 11-beta on the Testosterone molecule. The addition of the methyl group at carbon 17-alpha is what grants the hormone with the ability to survive metabolism in the liver, and therefore allow the hormone to be ingested orally and have the majority of the hormone successfully reach the blood stream to do its job in the body. Unfortunately it is this modification that also increases the hepatotoxicity (liver toxicity) of the anabolic steroid due to the fact that this modification allows the hormone to become further resistant to hepatic metabolism, and when a substance becomes further resistant to hepatic metabolism, increased liver strain and toxicity results. The halogenation previously mentioned is what is responsible for the massive increase in androgenic and anabolic strength in comparison to Testosterone and Methyltestosterone. Finally, the addition of the hydroxyl group at carbon 11-beta is what is responsible for restricting the ability for Halobol to interact with the aromatase enzyme, and therefore become unable to convert into Estrogen in the body. Halobol is an extremely strong and potent anabolic steroid analogue, possessing an anabolic strength 19 times the strength of Testosterone, and an androgenic strength 8. However, it has also been clarified that it has been determined to possess slightly less anabolic strength in humans in practicality, buy nandrobolin 250 mg injectable steroids $63.00 deca durabolin, deca. Athletes and bodybuilders should enjoy experiencing a vast increase in strength, lean muscle growth, and an increase in definition. Size increases have purported to be modest but not extreme. The methylation of the 17th carbon (also known as C17-alpha alkylation) presents the disadvantage of Halobol causing a degree of hepatotoxicity in the body, and this has been covered. The degree to which this hepatotoxicity presents itself will be further expanded upon in the Halobol side effects section of this article. This is a factor that must be considered and kept in mind by any potential users who which to use Halobol. Finally, because of its inability to interact with the aromatase enzyme and thereby avoid any Estrogen conversion, no risk of any Estrogen-related side effects at any dose should be seen with Halo. This means that users can expect no water retention that would lead to the puffy, bloated, and soft look that is often undesirable, especially during periods of cutting and fat loss, and pre-contest phases for competitive bodybuilders.
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